Journal article
The 4q27 locus and prostate cancer risk
EA Tindall, HN Hoang, MC Southey, DR English, JL Hopper, GG Giles, G Severi, VM Hayes
BMC Cancer | BIOMED CENTRAL LTD | Published : 2010
Abstract
Background: Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region on chromosome 4q27 and prostate cancer risk. This region harbors two cytokine genes IL-2 and the recently described IL-21.Methods: We genotyped six variants previously associated with autoimmune disease (namely rs13151961, rs13119723, rs17388568, rs3136534, rs6822844 and rs6840978) and one functional IL-2 promoter variant (rs2069762) for possible association with prostate cancer risk using the Australian Risk Factors for Prostate Cancer case-control Study.Results: Overall, ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
We are grateful to the study participants, as well as the many urologists, nurses and histopathologists who kindly facilitated in the recruitment and collection of patient information and pathology reports. This study was supported by grants from the National Health and Medical Research Council (# 396407, # 504700, and # 504702), Cancer Institute of New South Wales (VMH is a Fellow and EAT a PhD Scholar), and Australian Rotary Health Research (EAT is a PhD Scholar). Infrastructure support was provided from the Children's Cancer Institute Australia for Medical Research, the Cancer Council Victoria and from the Australian Cancer Research Foundation Unit for the Molecular Genetics of Cancer (located at the Garvan Institute for Medical Research, for Sequenom generated data).